Chabamide, a Novel Piperine Dimer from Stems of Piper chaba

Abstract

A novel piperine dimer, named chabamide, was isolated from stems of Piper chaba Hunter and its structure was elucidated on the basis of spectroscopic evidence. Chabamide showed antimalarial activity with an IC₅₀ value of 2.7 μg/ml and antituberculosis activity with the minimum inhibitory concentration (MIC) of 12.5 μg/ml.

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